Kiel, Germany Dec.13, 2005 – The first phase in the clinical trial of the newly developed drug Elafin has been successfully completed as announced by Proteo Biotech AG, a wholly owned subsidiary of Proteo Inc. (OTC BB: PTEO). Elafin, a recombinant human protein, is intended for the treatment of inflammatory diseases and is administered intravenously. The trial aimed to assess the safety and tolerability of this biotechnologically manufactured drug.
In the course of the last few weeks, Elafin has been tested on 32 healthy male volunteers at the Institut für Klinische Pharmakologie in Kiel, Germany. All intravenously applied doses were well tolerated. No severe adverse events occurred. Birge Bargmann, CEO of Proteo Biotech AG stated: "The successful conclusion of this trial demonstrates that the therapeutic use of proteins of human origin for these therapeutic purposes is associated with good tolerability. For further development of Elafin, we see a range of indications in the area of inflammatory diseases, particularly in circulatory and lung disorders."
Proteo owns the rights for the production and exploitation of recombinant Elafin. This protein was discovered at the Department of Dermatology of Kiel University, Germany. In humans it is produced in the skin, lungs and mammary glands and protects the Elafin producing cells from destruction by the immune system. Some organs, particularly muscles and blood vessels, do not express Elafin and are thus more susceptible to immune attack. Elafin's abil-ity to block the enzymes elastase and proteinase 3, both of which are involved in tissue damage during inflammatory reactions, makes this protein a promising agent for the treatment of inflammatory lung disorders or severe reperfusion injury occurring after heart attacks, woundings or organ transplantations.
Proteo Biotech AG researches, develops and markets substances for biological and medical research as well as for use as pharmaceuticals. The main focus lies in the development and up-scaling of production methods for active agents in inflammation research. The company was founded in Germany in April 2000 and in November of the same year became a wholly owned subsidiary of Proteo Inc., Irvine. Proteo Inc. intends to out license selected indications and to establish strategic alliances in the development of new applications as well as in marketing.
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