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Proteo, Inc. / Proteo Biotech AG: Positive ethical opinion for the coronary bypass trial Phase II

Irvine, CA – Kiel, 11th February 2011. – Proteo, Inc. (OTCBB: PTEO; Freiverkehr Frankfurt and Berlin WKN: 925981) and its wholly-owned subsidiary Proteo Biotech AG announced today:

Proteo Biotech AG/Proteo, Inc. and the University of Edinburgh, one of the leading European universities in the area of cardiovascular research, have made substantial progress in their collaboration. The purpose of the collaboration is the joint development of a concept for the EMPIRE (Elafin Myocardial Protection from Ischaemia RepErfusion injury) clinical trial.

This Phase II trial, in which the drug Elafin will be tested for the first time on bypass patients, was approved by the responsible Ethics Committee of NHS Scotland. Cardiac muscle inflammation following a bypass operation presents considerable problems. Dr. Peter Henriksen, consultant cardiologist at the Edinburgh Heart Centre and principle investigator of the trial: “There is a large body of evidence suggesting that intraoperatively administered Elafin will reduce injury to cardiac muscle following coronary bypass surgery.”

80 patients will participate in the placebo-controlled, double-blinded trial. The study will be funded by the Medical Research Council (MRC) and Chest Heart and Stroke Scotland (CHSS) with 500,000 GBP.

Further information on the clinical development program for Elafin

Proteo’s pharmaceutical Elafin is a copy of a naturally occurring human anti-inflammatory substance. It is a natural antagonist of the tissue destroying enzymes (proteases) that participate in the inflammatory mechanism of many diseases. Elafin’s ability to block the enzymes that cause these undesirable effects makes it a promising drug for the treatment of e.g. inflammatory lung diseases and severe reperfusion injury. The excellent tolerability of intravenously administered recombinant Elafin has already been demonstrated convincingly in a Phase I clinical trial. Currently, the results of a Phase II clinical trial on the treatment of postoperative inflammatory reactions in esophagus carcinoma are undergoing statistical analysis. In addition, Proteo’s licensing and development partner, Minapharm Pharmaceuticals SAE, has initiated a Phase II clinical trial on the use of Elafin for kidney transplantation patients. This trial is concerned with the prevention of acute organ rejection and chronic graft injury (allograft nephropathy).

About Proteo

The company researches, develops and markets compounds for biological and medical research as well as for use as pharmaceuticals. The main focus is on anti-inflammatory drugs, in particular on the human protease inhibitor Elafin. Proteo intends to out-license selected indications and to establish international strategic alliances in order to open up new fields of application and for marketing. (www.proteo.de).

Forward-Looking Statements

Certain statements in this news release may contain forward-looking information within the meaning of Rule 175 under the Securities Act of 1933 and Rule 3b-6 under the Securities Exchange Act of 1934, and are subject to the safe harbor created by those rules. All statements, other than statements of fact included in this release, including, without limitation, statements regarding potential future plans and objectives of the company, are forward-looking statements that involve risks and uncertainties. There can be no assurance that such statements will prove to be accurate and actual results and future events could differ materially from those anticipated in such statements. Technical complications that may arise could prevent the prompt implementation of any strategically significant plan(s) outlined above. The company cautions that these forward looking statements and risks and uncertainties involved are further qualified by other factors including, but not limited to those set forth in the company’s Form 10-K filing and other filings with the United States Securities and Exchange Commission. The company undertakes no obligation to publicly update or revise any statements in this release, whether as a result of new information, future events or otherwise.

Contact

Barbara Kahlke, Ph.D.
Proteo Biotech AG
Am Kiel-Kanal 44
D-24106 Kiel

Email: info@proteo.de
Telephone: +49 431 8888-462
Fax: +49 431 8888-463

https://proteo.de/pages/12/press-releases/2011/02/11/positive-ethical-opinion-for-the-coronary-bypass-trial-phase-ii/ – printed on 2018-08-16 2:21:37